Epsom is an unincorporated community in northern Franklin County and southern Vance County in North Carolina, United States. It is located on the county line, north-northwest of Louisburg and southeast of Henderson, at an elevation of 486 feet (148 m). The primary cross roads where the community is located are N.C. Highway 39, Epsom-Rocky Ford Road (SR 1003) and New Bethel Church Road (SR 1523). There was a post office in Epsom from September 27, 1887 to March 31, 1908. The first postmaster was Simon W. Duke.
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